Anti-Human IL6R Recombinant Antibody (TAB-026)
CAT#: TAB-026
Recombinant monoclonal antibody to Human IL6R. It is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer.
Tested Data
Gene Expression
ELISA
Figure 1 Anti-Human IL6R Antibody (TAB-026) in ELISA
ELISA analysis of TAB-026 was performed by coating with Recombinant Human IL6R Protein.
WB
Figure 2 Anti-Human IL6R Antibody (TAB-026) in WB
Western blot analysis of TAB-026 was performed with Recombinant Human IL6R Protein.
Lane 1: Non-Reducing Antigen (1 μg)
Lane 2: Reducing Antigen (1 μg)
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (THP-1, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000160712-IL6R
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Specifications
- Immunogen
- IL-6R bound to Sepharose4B.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- IgG1, kappa
- Specificity
- Tested positive against native human antigen
- Species Reactivity
- Human, Cynomolgus
- Applications
- ELISA, FC, IP, FuncS, IF, Neut, ICC
- MW
- 145.0 kDa
- Related Disease
- Cytokine Release Syndrome (CRS), Systemic Juvenile Idiopathic Arthritis (sJIA), Giant Cell Arteritis (GCA), and Rheumatoid Arthritis (RA)
Product Property
- Purification
- Protein A purified
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The IL6R antibody has been reported in applications of Inhibition.
Target
- Alternative Names
- IL6R; interleukin 6 receptor; interleukin-6 receptor subunit alpha; CD126; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha; gp80; IL6RA; IL-6RA; IL-6R-1; IL6Q; gp80; CD126; HIES5; IL-6R; IL6RA; IL6RQ; IL-1Ra; IL-6RA; IL6QTL;
- Gene ID
- 3570
- UniProt ID
- P08887
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Biosimilar Overview
Please refer to Tocilizumab-Atlizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tocilizumab-Atlizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L080E | IL6-PE immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L080D | IL6-DT immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-690LC-S(P) | Anti-human IL6R scFv Fragment (PM-1) | ELISA | |
| TAB-694LC-S(P) | Rabbit Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-694LC-S(P)) | ELISA | Rabbit scFv |
| TAB-690LC-F(E) | Anti-human IL6R Fab Fragment (PM-1) | ELISA | |
| TAB-694LC-F(E) | Rabbit Anti-IL6R Recombinant Antibody; Fab Fragment (TAB-694LC-F(E)) | ELISA | Rabbit Fab |
| TAB-695LC-F(E) | Rabbit Anti-IL6R Recombinant Antibody; Fab Fragment (TAB-695LC-F(E)) | ELISA | Rabbit Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-691LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-691LC-S(P)) | ELISA | Humanized scFv |
| TAB-692LC-S(P) | Anti-human IL6R scFv Fragment (TAB-692LC-S(P)) | ELISA | Humanized antibody |
| TAB-696LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-696LC-S(P)) | ELISA | Humanized scFv |
| TAB-697LC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (TAB-697LC-S(P)) | ELISA | Humanized scFv |
| TAB-032ML | Anti-Human IL6R Recombinant Antibody (TAB-032ML) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1485CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL212) | FC, ELISA, Neut | Mouse IgG1, κ |
| NEUT-1486CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL261) | FC, Neut | Mouse IgG1 |
| NEUT-1487CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL279) | Neut, WB, ELISA, FC | Mouse IgG1 |
| NEUT-1489CQ | Mouse Anti-IL6R Recombinant Antibody (clone CBL425) | WB, FC, CyTOF, ELISA, Neut | Mouse IgG1 |
| NEUT-1491CQ | Mouse Anti-IL6R Recombinant Antibody (clone MM0409-6M30) | WB, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1488CQ | Mouse Anti-IL6R Recombinant Antibody (clone B-F19) | Block | Mouse IgG1 |
| NEUT-1490CQ | Mouse Anti-IL6R Recombinant Antibody (clone B-R6) | IHC-Fr, Inhib, FC, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-YC | Human Anti-IL6R Recombinant Antibody (HPAB-0016-YC) | ELISA, Neut | Human IgG |
| HPAB-0446-WJ | Mouse Anti-IL6R Recombinant Antibody (HPAB-0446-WJ) | ELISA | Mouse IgG1 |
| HPAB-0447-WJ | Mouse Anti-IL6R Recombinant Antibody (HPAB-0447-WJ) | ELISA | Mouse IgG1 |
| HPAB-0448-WJ | Mouse Anti-IL6R Recombinant Antibody (HPAB-0448-WJ) | ELISA | Mouse IgG1 |
| HPAB-0449-WJ | Mouse Anti-IL6R Recombinant Antibody (HPAB-0449-WJ) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-YC-S(P) | Human Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0016-YC-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0446-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0446-WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-0447-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0447-WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-0448-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0448-WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-0449-WJ-S(P) | Mouse Anti-IL6R Recombinant Antibody; scFv Fragment (HPAB-0449-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016-YC-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0016-YC-F(E)) | ELISA, Neut | Human Fab |
| HPAB-1761LY-F(E) | Mouse Anti-IL6R Recombinant Antibody (clone G10); Fab Fragment | FC | Mouse Fab |
| HPAB-0165-YJ-F(E) | Human Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0165-YJ-F(E)) | ELISA, Block, Inhib | Humanized Fab |
| HPAB-0612-WJ-F(E) | Mouse Anti-IL6R Recombinant Antibody; Fab Fragment (HPAB-0612-WJ-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-AP718-YC-F(E) | Human Anti-IL6R Recombinant Antibody (clone A7); Fab Fragment | ELISA, Inhib, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-026 | Afuco™ Anti-IL6R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-026) | ELISA, FC, IP, FuncS, IF, Neut, ICC | ADCC enhanced antibody |
| AFC-TAB-032ML | Afuco™ Anti-IL6R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-032ML) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-691LC | Afuco™ Anti-IL6R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-691LC) | ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY152 | AbPlus™ Anti-IL6R Magnetic Beads (B-R6) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY12 | Human Anti-IL6R scFv-Fc Chimera (VS-0325-FY12) | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC585 | CytoStream™ Rabbit Anti-IL6R Recombinant Antibody (VS13-YC585) | WB, IHC-P, ICC, IF, FC, ELISA | Rabbit IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC677 | Recombinant Anti-IL6R Vesicular Antibody, EV Displayed (VS-0425-YC677) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3539 | Anti-IL6R Immunohistochemistry Kit | IHC | |
| VS-0525-XY3540 | Anti-Mouse IL6R Immunohistochemistry Kit | IHC |
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